POTENTIAL CONTAMINATION OF GROUNDWATER IN THE WORLD HERITAGE SITE OF SAINT KATHERINE PROTECTORATE, EGYPT

ABSTRACT Groundwater is the main water source for St. Katherine city inhabitants, South Sinai. The rapid population growth, high levels of tourism and poor sewage waste disposal (at least for the foreseeable future) in St. Katherine have resulted in potential contamination of groundwater and subsequent high risk to human health. To evaluate the safety of well water for human use in St. Katherine, water samples were collected from 14 different wells covering various inhabited locations in the area. These samples were subjected to extensive physical, chemical and microbiological analysis. Nitrate values of the majority of the studied wells water exceeded the accepted limits recommended by the Egyptian environmental legislations and the World Health Organization for drinking water standards. Counts of faecal indicators (faecal coliform and faecal streptococci) ranged between 2-142 cfu/100ml in wells. Bacterial pathogens including Salmonella, Shigella and Vibrio spp. were detectable in all wells, indicating heavy contamination of the groundwater with domestic sewage. We discuss the impact of the geological structure of the aquifers and human activities on the safety of groundwater for human use in St. Katherine, as well as possible solutions

An overview of agro‑food industry wastewater treatment: a bibliometric analysis and literature review

Agro-food (AF) industry provides great investment opportunities in its treated water and solid wastes, by conversion into value-added products. Our study accumulated extensive bibliometric data on this field from the Scopus database, between 1974 and 2021, and conducted a scientometric analysis using Science Mapping Analysis Software Tool (SciMAT) and VOSviewer for analyzing the retrieved data. The leading journals, highly used keywords in the published articles, authors and papers with the highest citations, and relevant regions were all identified in the scientometric analysis. Goal 6 of the Sustainable Development Goals (SDGs) pledge to “ensure the availability and sustainable access to water and sanitation for all.” To fulfill this demand, decentralized technologies are being developed. The scientometric analysis found significant flaws in previous studies on the adoption and use of decentralized treated AF wastewater, as well as its potential benefits for a sustainable future, particularly in the developing countries. Coagulation/electrocoagulation/ultrasonic processes, hybrid constructed wetlands and microbial inoculation are emerging efforts to achieve SDG6, particularly, in the emerging economy nations. Our scientometric findings can help academics collaborate on research, form joint ventures, and implement sophisticated technologies for treating AF wastewater and producing beneficial byproducts.Science and Technology Development Fund (STDF) 33534Egyptian Knowledge Bank (EKB

A bibliometric analysis and visualization of decision support systems for healthcare referral strategies

Background: The referral process is an important research focus because of the potential consequences of delays, especially for patients with serious medical conditions that need immediate care, such as those with metastatic cancer. Thus, a systematic literature review of recent and influential manuscripts is critical to understanding the current methods and future directions in order to improve the referral process. Methods: A hybrid bibliometric-structured review was conducted using both quantitative and qualitative methodologies. Searches were conducted of three databases, Web of Science, Scopus, and PubMed, in addition to the references from the eligible papers. The papers were considered to be eligible if they were relevant English articles or reviews that were published from January 2010 to June 2021. The searches were conducted using three groups of keywords, and bibliometric analysis was performed, followed by content analysis. Results: A total of 163 papers that were published in impactful journals between January 2010 and June 2021 were selected. These papers were then reviewed, analyzed, and categorized as follows: descriptive analysis (n = 77), cause and effect (n = 12), interventions (n = 50), and quality management (n = 24). Six future research directions were identified. Conclusions: Minimal attention was given to the study of the primary referral of blood cancer cases versus those with solid cancer types, which is a gap that future studies should address. More research is needed in order to optimize the referral process, specifically for suspected hematological cancer patients

О закономерностях распределения гелия в осадочном чехле юго-востока Беларуси

In this work, microscopic and histological studies suggest that Strobilanthes crispus ethanol extract reduce azoxymethane (AOM)-induced colonic aberrant crypt foci (ACF) in rats. S. crispus is considered a traditional medicine and used as an antioxidant. Its leaf contains a large amount of phenolic compounds to which its radical scavenging role is attributed and enhance its ability to eradicate oxidative stress reactions. The study was designed to determine the chemopreventive effect of S. crispus ethanol extract in vivo and in vitro by elucidating the effect of the extract on intermediate biomarkers which can be used as effective predictors of colon cancer. S. crispus was analyzed for DPPH free radical scavenging, nitric oxide (NO) and ferric acid reduction. The results indicated that S. crispus oral administration significantly inhibited colorectal carcinogenesis induced by AOM as revealed by the reduction in the number of ACF. S. crispus down-regulated the expression of PCNA, Bcl2 and beta-catenin. Additionally, it exerted a pronounced inhibitory effect on MDA and NO levels and stimulatory effect on CAT and GPx activities. These results demonstrate that S. crispus is a chemopreventive agent for colorectal cancer through the suppression of early and intermediate carcinogenic phases that may be related to its flavonoid content

The evolving SARS-CoV-2 epidemic in Africa: Insights from rapidly expanding genomic surveillance

INTRODUCTION Investment in Africa over the past year with regard to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) sequencing has led to a massive increase in the number of sequences, which, to date, exceeds 100,000 sequences generated to track the pandemic on the continent. These sequences have profoundly affected how public health officials in Africa have navigated the COVID-19 pandemic. RATIONALE We demonstrate how the first 100,000 SARS-CoV-2 sequences from Africa have helped monitor the epidemic on the continent, how genomic surveillance expanded over the course of the pandemic, and how we adapted our sequencing methods to deal with an evolving virus. Finally, we also examine how viral lineages have spread across the continent in a phylogeographic framework to gain insights into the underlying temporal and spatial transmission dynamics for several variants of concern (VOCs). RESULTS Our results indicate that the number of countries in Africa that can sequence the virus within their own borders is growing and that this is coupled with a shorter turnaround time from the time of sampling to sequence submission. Ongoing evolution necessitated the continual updating of primer sets, and, as a result, eight primer sets were designed in tandem with viral evolution and used to ensure effective sequencing of the virus. The pandemic unfolded through multiple waves of infection that were each driven by distinct genetic lineages, with B.1-like ancestral strains associated with the first pandemic wave of infections in 2020. Successive waves on the continent were fueled by different VOCs, with Alpha and Beta cocirculating in distinct spatial patterns during the second wave and Delta and Omicron affecting the whole continent during the third and fourth waves, respectively. Phylogeographic reconstruction points toward distinct differences in viral importation and exportation patterns associated with the Alpha, Beta, Delta, and Omicron variants and subvariants, when considering both Africa versus the rest of the world and viral dissemination within the continent. Our epidemiological and phylogenetic inferences therefore underscore the heterogeneous nature of the pandemic on the continent and highlight key insights and challenges, for instance, recognizing the limitations of low testing proportions. We also highlight the early warning capacity that genomic surveillance in Africa has had for the rest of the world with the detection of new lineages and variants, the most recent being the characterization of various Omicron subvariants. CONCLUSION Sustained investment for diagnostics and genomic surveillance in Africa is needed as the virus continues to evolve. This is important not only to help combat SARS-CoV-2 on the continent but also because it can be used as a platform to help address the many emerging and reemerging infectious disease threats in Africa. In particular, capacity building for local sequencing within countries or within the continent should be prioritized because this is generally associated with shorter turnaround times, providing the most benefit to local public health authorities tasked with pandemic response and mitigation and allowing for the fastest reaction to localized outbreaks. These investments are crucial for pandemic preparedness and response and will serve the health of the continent well into the 21st century

Reducing the environmental impact of surgery on a global scale: systematic review and co-prioritization with healthcare workers in 132 countries

Abstract Background Healthcare cannot achieve net-zero carbon without addressing operating theatres. The aim of this study was to prioritize feasible interventions to reduce the environmental impact of operating theatres. Methods This study adopted a four-phase Delphi consensus co-prioritization methodology. In phase 1, a systematic review of published interventions and global consultation of perioperative healthcare professionals were used to longlist interventions. In phase 2, iterative thematic analysis consolidated comparable interventions into a shortlist. In phase 3, the shortlist was co-prioritized based on patient and clinician views on acceptability, feasibility, and safety. In phase 4, ranked lists of interventions were presented by their relevance to high-income countries and low–middle-income countries. Results In phase 1, 43 interventions were identified, which had low uptake in practice according to 3042 professionals globally. In phase 2, a shortlist of 15 intervention domains was generated. In phase 3, interventions were deemed acceptable for more than 90 per cent of patients except for reducing general anaesthesia (84 per cent) and re-sterilization of ‘single-use’ consumables (86 per cent). In phase 4, the top three shortlisted interventions for high-income countries were: introducing recycling; reducing use of anaesthetic gases; and appropriate clinical waste processing. In phase 4, the top three shortlisted interventions for low–middle-income countries were: introducing reusable surgical devices; reducing use of consumables; and reducing the use of general anaesthesia. Conclusion This is a step toward environmentally sustainable operating environments with actionable interventions applicable to both high– and low–middle–income countries

Potential contamination of groundwater in the World Heritage Site of the St. Katherine Protectorate, Egypt

Groundwater is the main water source for St. Katherine city inhabitants, South Sinai. The rapid population growth, high levels of tourism and poor sewage waste disposal (at least for the foreseeable future) in St. Katherine have resulted in potential contamination of groundwater and subsequent high risk to human health. To evaluate the safety of well water for human use in St. Katherine, water samples were collected from 14 different wells covering various inhabited locations in the area. These samples were subjected to extensive physical, chemical and microbiological analysis. Nitrate values of the majority of the studied wells water exceeded the accepted limits recommended by the Egyptian environmental legislations and the World Health Organization for drinking water standards. Counts of faecal indicators (faecal coliform and faecal streptococci) ranged between 2-142 cfu/100ml in wells. Bacterial pathogens including Salmonella, Shigella and Vibrio spp. were detectable in all wells, indicating heavy contamination of the groundwater with domestic sewage. We discuss the impact of the geological structure of the aquifers and human activities on the safety of groundwater for human use in St. Katherine, as well as possible solutions. KEY WORDS: Sinai, wells , faecal coliform, faecal streptococci, pathogenic bacteria. Egyptian Journal of Botany Vol.5 2003: 1-